Effect of TNBS-induced morphological changes on pharmacological contractility of the rat ileum.

@article{Moreels2001EffectOT,
  title={Effect of TNBS-induced morphological changes on pharmacological contractility of the rat ileum.},
  author={Tom G. Moreels and Joris G. De Man and Jo{\"e}lle M. C. Dick and R J Nieuwendijk and Benedicte Y De Winter and Romain Adelin Lefebvre and Arnold G. Herman and Paul A. Pelckmans},
  journal={European journal of pharmacology},
  year={2001},
  volume={423 2-3},
  pages={211-22}
}
Intraluminal instillation of 2,4,6-trinitrobenzene sulfonic acid (TNBS) in ethanol is a classical model of colitis in the rat. Little is known about the time-related effect of TNBS on the contractility and morphology of the rat ileum. After 36 h, TNBS induced acute ileitis. Spontaneous activity of longitudinal muscle strips was decreased, as were receptor- and nonreceptor-mediated contractions and contractions induced by electrical stimulation. After 1 week, mucosal integrity was restored… CONTINUE READING