Effect of TGFβ and PDGF-B blockade on corneal myofibroblast development in mice.

@article{Singh2011EffectOT,
  title={Effect of TGFβ and PDGF-B blockade on corneal myofibroblast development in mice.},
  author={Vivek Singh and Marcony Rodrigues de Santhiago and Flavia L. Barbosa and Vandana Agrawal and Nirbhai Singh and Balamurali Krishna Ambati and Steven E. Wilson},
  journal={Experimental eye research},
  year={2011},
  volume={93 6},
  pages={810-7}
}
The purpose of this study was to investigate the role of transforming growth factor beta (TGFβ) and/or platelet-derived growth factor-B (PDGF-B) blockade on the differentiation of vimentin and alpha-smooth muscle actin (αSMA)-expressing myofibroblasts associated with haze in mice. Mouse corneas had haze-generating irregular PTK (phototherapeutic keratectomy) and topical treatment with the vectors. Six study groups of PTK treated corneas, with four corneas per group in each experiment, were… CONTINUE READING