Effect of TCDD on the density of Langerhans cells in murine skin.

Abstract

Tetrachlorodibenzo-p-dioxin (TCDD) is a prototype for a group of toxic polyhalogenated aromatic hydrocarbons. We have studied the effect of TCDD on skin, specifically the difference in cutaneous response of congenic haired (hr/+) and hairless (hr/hr) mice. Topical application of 0.6 microgram of TCDD induces epidermal hyperplasia/hyperkeratinization in the… (More)

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Cite this paper

@article{Puhvel1989EffectOT, title={Effect of TCDD on the density of Langerhans cells in murine skin.}, author={S. Madli Puhvel and M. Sakamoto and R. M. Reisner}, journal={Toxicology and applied pharmacology}, year={1989}, volume={99 1}, pages={72-80} }