Effect of TAK‐085 on Low‐density Lipoprotein Particle Size in Patients with Hypertriglyceridemia: A Double‐blind Randomized Clinical Study

@article{Tatsuno2015EffectOT,
  title={Effect of TAK‐085 on Low‐density Lipoprotein Particle Size in Patients with Hypertriglyceridemia: A Double‐blind Randomized Clinical Study},
  author={Ichiro Tatsuno and Kentarou Kudou and Tomoya Kagawa},
  journal={Cardiovascular Therapeutics},
  year={2015},
  volume={33},
  pages={317 - 323}
}
Summary Background Low‐density lipoproteins (LDLs) comprise a heterogeneous group of particles with various size and density. A shift to larger LDL particle size is mainly the result of a decrease in small dense LDL (sd‐LDL) levels and an increase in large buoyant LDL (lb‐LDL) levels. Methods In a randomized, double‐blind study of TAK‐085 (containing docosahexaenoic and eicosapentaenoic acid‐ethyl esters [EPA‐E]) and an EPA‐E product in Japanese patients with hypertriglyceridemia, exploratory… Expand
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Keywords: cardiovascular outcomes, eicosapentaenoic acid, fibric acids, niacin, omega-3 fatty acids, triglycerides Abbreviations AACE = American Association of Clinical Endocrinologists; ACCORD = Action to Control Cardiovascular Risk in Diabetes; AIM-HIGH = Atherothrombosis Intervention in Metabolic
© 2016 AACE ENDOCRINE PRACTICE Rapid Electronic Article in Press Rapid Electronic Articles in Press are preprinted manuscripts that have been reviewed and accepted for publication, but have yet to beExpand

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