Effect of T helper cell 1/T helper cell 2 balance and nuclear factor-κB on white matter injury in premature neonates.

  title={Effect of T helper cell 1/T helper cell 2 balance and nuclear factor-$\kappa$B on white matter injury in premature neonates.},
  author={Xuewen Su and Haifeng Yuan and Hongwei Cui and Hua Zhu and Xia Yun and Wenyan Tang and Junlong Chen and Zu Luan},
  journal={Molecular medicine reports},
  volume={17 4},
Incidence of white matter injury (WMI), which is featured as softening of white matter tissues, has recently increased. Previous studies have demonstrated a close correlation between T helper cell 1 and T helper cell 2 (Th1/Th2) imbalance and nuclear factor‑κB (NF‑κB) with brain disease. Their role in premature WMI, however, remains to be illustrated. Serum samples were collected from 60 premature WMI neonates, plus another control group of 60 premature babies without WMI. Patients were further… 
5 Citations
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In utero injury primes the immune system and augments enhanced inflammatory signaling, and the insidious effects of primed peripheral immune cells may compound PBI secondary to CHORIO and/or placental insufficiency, and render the brain susceptible to future chronic neurological disease.
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Singleton premature infants conceived by ART have a higher risk of WMI than NC infants, and more attention should be paid to neurodevelopmental outcomes in this group.


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Higher frequencies of Th1 cells and activated memory B cells were associated with type III asymptomatic MC in HCV infection, and the frequency of Th2, Th17, follicular helper T (Tfh cells), Th22, and tissue-like B Cells were significantly higher in CHC patients compared to HCs, while these cell subsets were not significantly different betweenCHC patients and HCV-related MC patients.
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Th subsets in BM are distinct for different stages of AML and chemotherapy partly ameliorates the abnormality, suggesting that these cells and cytokines may be implicated in AML pathogenesis and provided therapeutic insights.
Th1, Th2, Th17 and Treg levels in umbilical cord blood in preeclampsia
  • M. I. Vargas-Rojas, H. Solleiro-Villavicencio, E. Soto-Vega
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
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The results show that there is a shift, in the Th1/Th2, and the Th17/Treg balance, favoring skewness towards a proinflammatory status in the umbilical cord blood in preeclampsia.
Increased IL-12 and decreased IL-33 serum levels are associated with increased Th1 and suppressed Th2 cytokine profile in patients with diabetic nephropathy (CURES-134).
The IL-33 levels showed a serial decline with increasing severity of insulin resistance and microalbuminuria and DN was associated with enhanced Th1 response and suppression of Th2 responses which might be due to inreased levels of IL-12 and decreased levels ofIL-33 cytokines respectively.
APE1/Ref-1 facilitates recovery of gray and white matter and neurological function after mild stroke injury
It is concluded that APE1 dictates fundamental life and death decisions in both gray and white matter and plays an indispensable role in intrinsic recovery after mild ischemic injury, and provides evidence that endogenous APE 1 protects against isChemic infarction in bothgray andwhite matter and facilitates the functional recovery of the central nervous system after mild stroke injury.
Modulatory Role of Omentin-1 in Inflammation: Cytokines and Dietary Intake
Omentin-1 has an anti-inflammatory role in obesity and exerts its effects probably by inducing an increase in Th-2 cytokines comprising IL-13 and IL-4, which modulates T helper balance.
Th1-Like ICOS+ Foxp3+ Treg Cells Preferentially Express CXCR3 and Home to β-Islets during Pre-Diabetes in BDC2.5 NOD Mice
An ICOS-dependent mechanism of Treg cell homing to the β-islets during pre-diabetes in the NOD model via upregulation of the CXCR3 chemokine receptor is proposed, which could represent a mechanism of homeostatic immunoregulation during diabetogeneesis.