Effect of Synthetic Ligands of PPAR α, β/δ, γ, RAR, RXR and LXR on the Fatty Acid Composition of Phospholipids in Mice

@article{Weiss2011EffectOS,
  title={Effect of Synthetic Ligands of PPAR α, β/δ, γ, RAR, RXR and LXR on the Fatty Acid Composition of Phospholipids in Mice},
  author={Kathrin Weiss and Johanna Mih{\'a}ly and Gerhard Liebisch and Tam{\'a}s Marosv{\"o}lgyi and Gerd Schmitz and Tam{\'a}s Decsi and Ralph R{\"u}hl},
  journal={Lipids},
  year={2011},
  volume={46},
  pages={1013-1020}
}
Nuclear hormone receptors are transcription factors that can be activated by nutrition-derived ligands and alter the expression of various specific target genes. Stearoyl-Coenzyme A desaturase (SCD1) converts palmitic acid (16:0) to palmitoleic acid (16:1n-7) as well as stearic acid (18:0) to oleic acid (18:1n-9). At the same time, elongase 6 (ELOVL6) elongates 16:1n-7 and 18:1n-9 to vaccenic acid (18:1n-7) and eicosenoic acid (20:1n-9). We examined how synthetic selective ligands of nuclear… CONTINUE READING
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