Effect of Surgery on Pancreatic Tumor-Dependent Lymphocyte Asset

  title={Effect of Surgery on Pancreatic Tumor-Dependent Lymphocyte Asset},
  author={Francesco Iannone and Alessandra Porzia and Giovanna Peruzzi and Patrizia Birarelli and Bernardina Milana and Luca Sacco and Giuseppe Dinatale and Nadia Peparini and Giampaolo Prezioso and Simone Battella and Roberto Caronna and Stefania Morrone and Gabriella Palmieri and Fabrizio Mainiero and Piero Chirletti},
OBJECTIVES Tumor burden and invasiveness establish a microenvironment that surgery could alter. This study shows a comprehensive analysis of size, dynamics, and function of peripheral lymphocyte subsets in pancreatic cancer patients before and at different times after duodenopancreatectomy. METHODS Lymphocyte frequency and natural cytotoxicity were evaluated by flow cytometry and in vitro assay on peripheral blood from initial and advanced-stage pancreatic cancer patients before (BS), at day… CONTINUE READING
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