Effect of Study Design on the Reported Effect of Cardiac Resynchronization Therapy (CRT) on Quantitative Physiological Measures: Stratified Meta‐Analysis in Narrow‐QRS Heart Failure and Implications for Planning Future Studies

@inproceedings{Jabbour2015EffectOS,
  title={Effect of Study Design on the Reported Effect of Cardiac Resynchronization Therapy (CRT) on Quantitative Physiological Measures: Stratified Meta‐Analysis in Narrow‐QRS Heart Failure and Implications for Planning Future Studies},
  author={Richard J. Jabbour and Matthew J. Shun‐Shin and Judith A. Finegold and S. M. Afzal Sohaib and Christopher Cook and Sukhjinder Singh Nijjer and Zachary I. Whinnett and Charlotte H. Manisty and Josep Brugada and Darrel P. Francis},
  booktitle={Journal of the American Heart Association},
  year={2015}
}
BACKGROUND Biventricular pacing (CRT) shows clear benefits in heart failure with wide QRS, but results in narrow QRS have appeared conflicting. We tested the hypothesis that study design might have influenced findings. METHOD AND RESULTS We identified all reports of CRT-P/D therapy in subjects with narrow QRS reporting effects on continuous physiological variables. Twelve studies (2074 patients) met these criteria. Studies were stratified by presence of bias-resistance steps: the presence of… CONTINUE READING