Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects.

@article{Jiang2004EffectOS,
  title={Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects.},
  author={Xuemin Jiang and Kenneth Mapson Williams and Winston Spencer Liauw and Alaina J Ammit and Basil D. Roufogalis and Colin C. Duke and Richard O. Day and Andrew J. McLachlan},
  journal={British journal of clinical pharmacology},
  year={2004},
  volume={57 5},
  pages={592-9}
}
UNLABELLED M: The aim of this study was to investigate the effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin. METHODS This was an open-label, three-way crossover randomized study in 12 healthy male subjects, who received a single 25-mg dose of warfarin alone or after 14 days' pretreatment with St John's wort, or 7 days' pretreatment with ginseng. Dosing with St John's wort or ginseng was continued for 7 days after administration of the warfarin dose… CONTINUE READING
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