Effect of Solution Phase Composition on the Interaction Between Aqueous Model Solutes and Polymeric Container Materials

@article{Jenke1991EffectOS,
  title={Effect of Solution Phase Composition on the Interaction Between Aqueous Model Solutes and Polymeric Container Materials},
  author={Dennis R. Jenke},
  journal={Pharmaceutical Research},
  year={1991},
  volume={8},
  pages={782-786}
}
The interaction between several marker solutes and a polyolefin laminate polymer was studied in several solutions. Solutions studied included mixtures of sodium chloride and dextrose (at concentrations more less typical of iv administration solutions) and several actual iv products [lactated Ringer's injection, Dianeal, Travasol (amino acid) injection, and alcohol/dextrose injection]. The interaction properties of the candidate container material correlated well with the solute's octanol–water… CONTINUE READING