Effect of Single and Multiple Courses of Prenatal Corticosteroids on 17-Hydroxyprogesterone Levels: Implication for Neonatal Screening of Congenital Adrenal Hyperplasia

@article{Gatelais2004EffectOS,
  title={Effect of Single and Multiple Courses of Prenatal Corticosteroids on 17-Hydroxyprogesterone Levels: Implication for Neonatal Screening of Congenital Adrenal Hyperplasia},
  author={Fr{\'e}d{\'e}rique Gatelais and Jacques Berthelot and Fr{\'e}d{\'e}rique B{\'e}ringue and Philippe Descamps and D. Bonneau and Jean-Marie Limal and Regis Coutant},
  journal={Pediatric Research},
  year={2004},
  volume={56},
  pages={701-705}
}
Measurement of 17-hydroxyprogesterone (17-OHP) from filter-paper blood is widely used to screen for congenital adrenal hyperplasia (CAH). However, in pregnancies with an expected preterm delivery, prenatal treatment with steroids to induce pulmonary maturation could suppress the fetal adrenals and interfere with this screening. In 160 infants who were born between 25 and 35 wk of gestation, we measured 17-OHP in filter-paper blood at 72–96 h and compared the values between those who had not… CONTINUE READING

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