Effect of Sinc genotype, agent isolate and route of infection on the accumulation of protease-resistant PrP in non-central nervous system tissues during the development of murine scrapie.

@article{Farquhar1994EffectOS,
  title={Effect of Sinc genotype, agent isolate and route of infection on the accumulation of protease-resistant PrP in non-central nervous system tissues during the development of murine scrapie.},
  author={Christine F. Farquhar and James Dornan and Robert A. Somerville and Anita M Tunstall and James Jerry Luckyboy Hope},
  journal={The Journal of general virology},
  year={1994},
  volume={75 ( Pt 3)},
  pages={
          495-504
        }
}
Mice congenic for the Sinc gene were infected intracerebrally with two scrapie strains, ME7 and 22A. At various times during the incubation period tissues were monitored for the infection-specific form of PrP (PrPSc). PrPSc was found in brain, spleen, lymph nodes, pancreas, submaxillary gland and thymus. After intraperitoneal inoculation PrPSc was found in spleen, lymph nodes, pancreas and submaxillary glands prior to its detection in brain. The kinetics of accumulation of PrPSc in these… CONTINUE READING

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