Effect of Shengmai-san on cognitive performance and cerebral oxidative damage in BALB/c mice.

@article{Giridharan2011EffectOS,
  title={Effect of Shengmai-san on cognitive performance and cerebral oxidative damage in BALB/c mice.},
  author={Vijayasree V. Giridharan and Rajarajan A Thandavarayan and Tetsuya Konishi},
  journal={Journal of medicinal food},
  year={2011},
  volume={14 6},
  pages={
          601-9
        }
}
The aim of this study was to examine the effect of Shengmai-san (SMS) on learning and memory impairment induced by scopolamine (1 mg/kg, i.p.) in mice. The passive avoidance task (PAT) and Morris water maze (MWM) test served as the behavioral models for testing memory. To elucidate the mechanism of its cognitive-enhancing activity, the effects of SMS (2, 4, or 8 g/kg) on activities of acetylcholinesterase (AChE) and antioxidant enzymes and levels of acetylcholine (ACh) and nitrite were… Expand
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