Effect of Selective Estrogen Receptor Modulator/Raloxifene Analogue on Proliferation and Collagen Metabolism of Tendon Fibroblast

  title={Effect of Selective Estrogen Receptor Modulator/Raloxifene Analogue on Proliferation and Collagen Metabolism of Tendon Fibroblast},
  author={T. Irie and M. Takahata and T. Majima and Yuichiro Abe and M. Komatsu and N. Iwasaki and A. Minami},
  journal={Connective Tissue Research},
  pages={179 - 187}
  • T. Irie, M. Takahata, +4 authors A. Minami
  • Published 2010
  • Chemistry, Medicine
  • Connective Tissue Research
  • The selective estrogen receptor modulator raloxifene is therapeutically beneficial for postmenopausal connective tissue degradation, such as osteoporosis, vascular sclerosis, and dermal degradation; however, the effects of raloxifene on postmenopausal tendon metabolism have not been clarified. In this study, we investigated the effects of raloxifene analogue (LY117018) on cell proliferation and collagen metabolism using cultured rat Achilles tendon fibroblasts. 17β-Estradiol (E2; 10−11–10−9 M… CONTINUE READING
    30 Citations
    Dose-dependent regulation of cell proliferation and collagen degradation by estradiol on ligamentum flavum
    • 7
    • PDF
    The effect of raloxifene, a SERM, on extracellular matrix protein expression of pelvic fibroblasts
    • 4
    Estrogen improves TIMP-MMP balance and collagen distribution in volume-overloaded hearts of ovariectomized females.
    • 77
    • PDF
    A Combination Treatment of Raloxifene and Vitamin D Enhances Bone-to-Tendon Healing of the Rotator Cuff in a Rat Model
    Effects of transdermal estrogen on collagen turnover at rest and in response to exercise in postmenopausal women.
    • 26
    • PDF
    The soy isoflavone genistein inhibits the reduction in Achilles tendon collagen content induced by ovariectomy in rats
    • 13
    Effect of Raloxifene on Arthritis and Bone Mineral Density in Rats with Collagen-Induced Arthritis
    • 3
    • PDF


    Differential effects of estradiol and raloxifene on collagen biosynthesis in cultured human skin fibroblasts.
    • 58
    Estrogen and extracellular matrix influence human gingival fibroblast proliferation and protein production.
    • A. Mariotti
    • Biology, Medicine
    • Journal of periodontology
    • 2005
    • 27
    Effects of estradiol and raloxifene on arterial thrombosis in ovariectomized mice
    • 12
    Effect of estrogen on cellular metabolism of the human anterior cruciate ligament.
    • 133
    Estrogen Affects the Cellular Metabolism of the Anterior Cruciate Ligament
    • 271
    Raloxifene, a mixed estrogen agonist/antagonist, induces apoptosis in androgen-independent human prostate cancer cell lines.
    • 107