Effect of Schistosoma mansoni-induced granulomatous inflammation on murine gastrointestinal motility.

@article{Moreels2001EffectOS,
  title={Effect of Schistosoma mansoni-induced granulomatous inflammation on murine gastrointestinal motility.},
  author={Tom G. Moreels and Joris G. De Man and J. J. P. M. Bogers and Benedicte Y De Winter and Gunther Vrolix and Arnold G. Herman and E A Van marck and Paul A. Pelckmans},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2001},
  volume={280 5},
  pages={G1030-42}
}
In Schistosoma mansoni-infected mice, gastrointestinal transit was measured in vivo and the neuromuscular function of longitudinal muscle strips of inflamed ileum and noninflamed gastric fundus was assessed in vitro. Eight weeks after infection, the ileal wall was acutely inflamed, as shown by a mucosal inflammatory infiltrate, leading to an increase in mucosal thickness, in myeloperoxidase (MPO) activity, and in interleukin (IL)-1beta production. At that time, both gastrointestinal transit and… CONTINUE READING
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The immunomodulation of enteric neuromuscular function: implications for motility and inflammatory disorders

  • SM Collins
  • Gastroenterology 111:
  • 1996
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