Effect of Schistosoma mansoni Infection on Innate and HIV-1-Specific T-Cell Immune Responses in HIV-1-Infected Ugandan Fisher Folk

@inproceedings{Obuku2016EffectOS,
  title={Effect of Schistosoma mansoni Infection on Innate and HIV-1-Specific T-Cell Immune Responses in HIV-1-Infected Ugandan Fisher Folk},
  author={Andrew Ekii Obuku and Gershim Asiki and Andrew Abaasa and Isaac Ssonko and Alexandre Harari and Govert J van Dam and Paul L. Corstjens and Moses Joloba and Song Ding and Juliet Mpendo and Leslie Nielsen and Anatoli Kamali and Alison M Elliott and Giuseppe Pantaleo and Pontiano Kaleebu and Pietro Pala},
  booktitle={AIDS research and human retroviruses},
  year={2016}
}
  • Andrew Ekii Obuku, Gershim Asiki, +13 authors Pietro Pala
  • Published in
    AIDS research and human…
    2016
  • Medicine
  • In Uganda, fisher folk have HIV prevalence rates, about four times higher than the national average, and are often coinfected with Schistosoma mansoni. We hypothesized that innate immune responses and HIV-specific Th1 immune responses might be downmodulated in HIV/S. mansoni-coinfected individuals compared with HIV+/S. mansoni-negative individuals. We stimulated whole blood with innate receptor agonists and analyzed supernatant cytokines by Luminex. We evaluated HIV-specific responses by… CONTINUE READING

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