Effect of Schistosoma mansoni Infection on Innate and HIV-1-Specific T-Cell Immune Responses in HIV-1-Infected Ugandan Fisher Folk

@article{Obuku2016EffectOS,
  title={Effect of Schistosoma mansoni Infection on Innate and HIV-1-Specific T-Cell Immune Responses in HIV-1-Infected Ugandan Fisher Folk},
  author={A. Obuku and G. Asiki and A. Abaasa and Isaac Ssonko and A. Harari and G. V. van Dam and P. Corstjens and M. Joloba and S. Ding and J. Mpendo and L. Nielsen and A. Kamali and A. Elliott and G. Pantaleo and P. Kaleebu and P. Pala},
  journal={AIDS Research and Human Retroviruses},
  year={2016},
  volume={32},
  pages={668 - 675}
}
Abstract In Uganda, fisher folk have HIV prevalence rates, about four times higher than the national average, and are often coinfected with Schistosoma mansoni. We hypothesized that innate immune responses and HIV-specific Th1 immune responses might be downmodulated in HIV/S. mansoni-coinfected individuals compared with HIV+/S. mansoni-negative individuals. We stimulated whole blood with innate receptor agonists and analyzed supernatant cytokines by Luminex. We evaluated HIV-specific responses… Expand
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