Effect of SULT1A1 and NAT2 genetic polymorphism on the association between cigarette smoking and colorectal adenomas.

@article{Tiemersma2004EffectOS,
  title={Effect of SULT1A1 and NAT2 genetic polymorphism on the association between cigarette smoking and colorectal adenomas.},
  author={Edine Tiemersma and Annelies E. Bunschoten and FransJ. Kok and Hansruedi Glatt and Sybrand Y de Boer and Ellen Kampman},
  journal={International journal of cancer},
  year={2004},
  volume={108 1},
  pages={
          97-103
        }
}
Cigarette smoke contains polycyclic hydrocarbons and arylamines that may both be activated by sulfotransferase, encoded by SULT1A1. A genetic polymorphism leads to an Arg213His substitution, thereby decreasing enzyme activity and stability and might thus modify the association between smoking and colorectal adenomas. We investigated this in a Dutch case-control study. Additionally, we evaluated potential roles of epoxide hydrolase (EPHX), N-acetyltransferases (NAT1 and NAT2) and glutathione S… CONTINUE READING
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