Effect of SCP-x gene ablation on branched-chain fatty acid metabolism.

  title={Effect of SCP-x gene ablation on branched-chain fatty acid metabolism.},
  author={B. Atshaves and A. McIntosh and Danilo Landrock and H. Payne and J. Mackie and N. Maeda and Judith Ball and F. Schroeder and A. Kier},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={292 3},
  • B. Atshaves, A. McIntosh, +6 authors A. Kier
  • Published 2007
  • Medicine, Biology
  • American journal of physiology. Gastrointestinal and liver physiology
  • Despite the importance of peroxisomal oxidation in branched-chain lipid (phytol, cholesterol) detoxification, little is known regarding the factors regulating the peroxisomal uptake, targeting, and metabolism of these lipids. Although in vitro data suggest that sterol carrier protein (SCP)-x plays an important role in branched-chain lipid oxidation, the full physiological significance of this peroxisomal enzyme is not completely clear. To begin to resolve this issue, SCP-x-null mice were… CONTINUE READING
    51 Citations
    Impact of dietary phytol on lipid metabolism in SCP2/SCPX/L-FABP null mice.
    • 9
    Sex-dependent impact of Scp-2/Scp-x gene ablation on hepatic phytol metabolism.
    • 2
    Impact of SCP-2/SCP-x gene ablation and dietary cholesterol on hepatic lipid accumulation.
    • 25
    • PDF
    Sterol carrier protein-2: new roles in regulating lipid rafts and signaling.
    • 71
    Effect of Fabp1/Scp-2/Scp-x Ablation on Whole Body and Hepatic Phenotype of Phytol-Fed Male Mice
    • 5
    Impact of Fabp1/Scp-2/Scp-x gene ablation (TKO) on hepatic phytol metabolism in mice[S]
    • 7
    • PDF
    Phytol-induced pathology in 2-hydroxyacyl-CoA lyase (HACL1) deficient mice. Evidence for a second non-HACL1-related lyase.
    • 7
    Phytol-induced Hepatotoxicity in Mice
    • 34


    Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function.
    • 255
    • PDF
    Sexually dimorphic metabolism of branched-chain lipids in C57BL/6J mice Published, JLR Papers in Press, March 1, 2004. DOI 10.1194/jlr.M300408-JLR200
    • 59
    • PDF
    Effect of branched-chain fatty acid on lipid dynamics in mice lacking liver fatty acid binding protein gene.
    • 49
    • PDF
    Phytanic acid is ligand and transcriptional activator of murine liver fatty acid binding protein.
    • 117
    Expression of fatty acid binding proteins inhibits lipid accumulation and alters toxicity in L cell fibroblasts.
    • 83
    • PDF
    Liver Fatty Acid-binding Protein Gene Ablation Inhibits Branched-chain Fatty Acid Metabolism in Cultured Primary Hepatocytes*
    • 91
    • PDF
    Sterol carrier protein-2.
    • 137