Effect of SCFA on intracellular pH and intracellular pH regulation of guinea-pig caecal and colonic enterocytes and of HT29-19a monolayers.

@article{Busche1997EffectOS,
  title={Effect of SCFA on intracellular pH and intracellular pH regulation of guinea-pig caecal and colonic enterocytes and of HT29-19a monolayers.},
  author={Roger Busche and Joerg Bartels and A K Genz and Wolfgang von Engelhardt},
  journal={Comparative biochemistry and physiology. Part A, Physiology},
  year={1997},
  volume={118 2},
  pages={395-8}
}
The response of the intracellular pH (pHi, measured with BCECF) of the caecal and distal colonic epithelium of guinea pig and of monolayers of HT29 clone 19a cells on the addition of short-chain fatty acids (SCFA) was assessed. Addition of SCFA to the luminal side of these cells had no major effect on pHi, independent of whether the apical Na+/H+ exchange or the apical K+/H+ ATPase was inhibited or not. Addition of SCFA to the serosal side, on the other hand, caused a marked decrease of pHi… CONTINUE READING

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