Corpus ID: 25416098

Effect of SA-103 on experimental allergic models in vivo and in vitro--comparison with disodium cromoglycate.

@article{Nabe1992EffectOS,
  title={Effect of SA-103 on experimental allergic models in vivo and in vitro--comparison with disodium cromoglycate.},
  author={T. Nabe and H. Yamamura and S. Kohno and K. Ohata},
  journal={Arerugi = [Allergy]},
  year={1992},
  volume={41 6},
  pages={
          676-85
        }
}
  • T. Nabe, H. Yamamura, +1 author K. Ohata
  • Published 1992
  • Chemistry, Medicine
  • Arerugi = [Allergy]
  • The anti-allergic action of N-[4-(4-methoxyphenyl)-2-thiazolyl]-1H-tetrazol-5-carboxamide (SA-103) was investigated and compared with that of disodium cromoglycate (DSCG). 1) Oral administration of SA-103 (0.1-10 mg/kg, p.o.) showed dose-dependent inhibition of 48 hr homologous passive cutaneous anaphylaxis (PCA) in rats. The inhibition rate (50%) of the compound at 1 mg/kg was comparable to that of DSCG at 1 mg/kg (i.v.). 2) Both of the drugs concentration-dependently inhibited the release of… CONTINUE READING
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