Effect of S-methyl cysteine sulphoxide and its metabolite methyl methane thiosulphinate, both occurring naturally in Brassica vegetables, on mouse genotoxicity.

@article{Marks1993EffectOS,
  title={Effect of S-methyl cysteine sulphoxide and its metabolite methyl methane thiosulphinate, both occurring naturally in Brassica vegetables, on mouse genotoxicity.},
  author={H S Marks and J. A. Anderson and G S Stoewsand},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1993},
  volume={31 7},
  pages={491-5}
}
S-methyl cysteine sulphoxide (SMCSO) and its metabolite methyl methane thiosulphinate (MMTSO), both naturally occurring compounds present in Brassica vegetables, were investigated for their putative ability to inhibit benzo[a]pyrene (B[a]P)-induced genotoxicity in ICR mice. The mouse bone marrow micronucleus assay was used as an indicator of in vivo genotoxicity. Doses of 0.5 mmol SMCSO and 0.05mmol MMTSO per kg body weight significantly inhibited the formation of B[a]P-induced micronucleated… CONTINUE READING