Effect of S-312, a new calcium channel blocker, on the 1,4-dihydropyridine binding sites in porcine basilar blood vessels and rat aortic smooth muscle cells.

@article{Mihara1991EffectOS,
  title={Effect of S-312, a new calcium channel blocker, on the 1,4-dihydropyridine binding sites in porcine basilar blood vessels and rat aortic smooth muscle cells.},
  author={S. Mihara and M. Fujimoto},
  journal={Japanese journal of pharmacology},
  year={1991},
  volume={56 3},
  pages={
          249-59
        }
}
We examined the interaction of two isomers of S-312, a new calcium channel blocker with a bicyclic dihydrothienopyridine structure, with 1,4-dihydropyridine binding sites. Specific bindings of [3H]nitrendipine and (+)-[3H] PN200-110 in membranes prepared from porcine basilar blood vessels were saturable, reversible, and stereoselective, and had high affinities. The binding properties were very similar to those in membranes from other tissues such as the aorta, myocardium, and cerebral cortex. 1… Expand
3 Citations
Activity of dihydrothienopyridine S312 enantiomers on L-type Ca2+ channels in isolated rat aorta and cerebral microvessels.
TLDR
It is concluded that the dihydrothienopyridine S312 could interact with Ca2+ channels in a manner different to that of genuine dihydropyridines. Expand
Pharmacological studies on a new dihydrothienopyridine calcium antagonist, S-312-d. 5th communication: anticonvulsant effects in mice.
TLDR
Although moderate anticonvulsant effects of S-312-d in higher doses were observed against the clonic convulsions induced by pentylenetetrazole or bemegride, no effects were observed in convulsion induced by N-methyl-D-aspartate, picrotoxin, or electroshock in Slc:ddY mice. Expand
Efficient regioselective one-pot synthesis of partially hydrogenated thiazolo[3,2-a]pyridines
Abstract 7 H -Thiazolo[3,2- a ]pyridin-3(2 H )-ones, 7 H -thiazolo[3,2- a ]pyridin-3(2 H )-imines, and 3-hydroxy-3-methyl(phenyl)-2,3-dihydro-7 H -thiazolo[3,2- a ]pyridines have been obtained inExpand

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