Effect of S(-) perillic acid on protein prenylation and arterial smooth muscle cell proliferation.

@article{Ferri2001EffectOS,
  title={Effect of S(-) perillic acid on protein prenylation and arterial smooth muscle cell proliferation.},
  author={Nicola Ferri and Lorenzo Arnaboldi and Augusto Orlandi and Keiko Yokoyama and Ren{\'e} Gr{\'e}{\'e} and Alessandra Granata and Ahmed Hachem and Rodolfo Paoletti and Michael H Gelb and A Corsini},
  journal={Biochemical pharmacology},
  year={2001},
  volume={62 12},
  pages={1637-45}
}
A number of proteins post-translationally modified by the covalent attachment of mevalonate-derived isoprene groups farnesol (FOH) or geranylgeraniol (GGOH), play a role in cell proliferation. For this reason, protein farnesyltransferase (PFTase) and protein geranylgeranyltransferases (PGGTases) I and II have gained attention as novel targets for the development of antiproliferative agents. Monoterpenes [limonene, perillic acid (PA) and its derivatives] have been shown to inhibit cell growth… CONTINUE READING