Effect of Reverse Iontophoresis on Theophylline Uptake by Hydrogel-forming Microneedle Arrays

SUMMARY A novel drug monitoring system was developed based on hydrogel-forming microneedle arrays capable of imbibing large amounts of fluid containing theophylline. The application of an electric current to the microneedles led to an increase in fluid up-taken. INTRODUCTION Hydrogels are cross-linked, macromolecular polymeric materials arranged in a… (More)