Effect of Renal Insufficiency upon Plasma Mag- Nesium and Magnesium Excretion after Ingestion of Magnesium Sulfate*

Abstract

Although epsom salt has been used as a cathartic since its introduction by Grew in 1675, little has been known regarding the amount of magnesium actually absorbed from the bowel and excreted by the kidneys; and the effect of renal insufficiency upon this process has been entirely overlooked. We have found in the literature only two determinations of magnesium in the urine after ingestion of epsom salt. Hay (1) found 28.1 per cent of the magnesium excreted in 24 hours after one normal individual ingested 20 gm. of epsom salt (MgS04.7H20) and Yvon (2) found 21 per cent excreted after the same dose. In seven normal individuals we found, using the analytical methods described in the previous papers (3, 4), that 40 to 44 per cent (average 42.6 per cent) of the ingested Mg was excreted in the urine in 24 hours, while the plasma magnesium rose from an average concentration of 1.85 mg. of Mg per 100 cc. to an average concentration of 2.09 mg. (The greatest increase was 0.4 mg. of Mg per 100 cc.) In normal dogs and normal rabbits which received even larger doses (1 gm. of MgSOc.7H20 per kilo by stomach tube), the per cent of magnesium excreted and the rise of plasma magnesium were about the same. When doses of MgS04.7Hz0 ranging from 2 gm. to 10 gm. per kilo were given by stomach tube to eleven normal rabbits, the per cent of magnesium excreted remained quite constant re-

Cite this paper

@inproceedings{Hirschfelder2003EffectOR, title={Effect of Renal Insufficiency upon Plasma Mag- Nesium and Magnesium Excretion after Ingestion of Magnesium Sulfate*}, author={Arthur D. Hirschfelder and G. HAWRY}, year={2003} }