Effect of Raf kinase inhibitor protein expression on malignant biological behavior and progression of colorectal cancer.

@article{Wang2015EffectOR,
  title={Effect of Raf kinase inhibitor protein expression on malignant biological behavior and progression of colorectal cancer.},
  author={Yun Wang and Ling-yun Wang and Fen Feng and Yang Zhao and Ma-yan Huang and Qiong Shao and Cui Chen and Hui Sheng and Dongliang Chen and Zhao-lei Zeng and Rui-hua Xu and Yu-hong Li},
  journal={Oncology reports},
  year={2015},
  volume={34 4},
  pages={
          2106-14
        }
}
The Raf kinase inhibitor protein (RKIP) is a novel metastasis suppressor. RKIP was previously found to have low expression in a colorectal cancer (CRC) patient cohort by immunohistochemistry. However, the role of RKIP in CRC remains undetermined. In the present study, immunohistochemistry was performed to compare RKIP expression between 129 paired stage II CRC and adjacent non-tumorous tissues. The correlations between clinical parameters, prognosis and RKIP expression were evaluated. To… 
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A review of RKIP promotion of tumor progression, metastasis and poor outcome in multiple solid tumor types
Theranostic role of RKIP in cancer
Implications of RKIP protein in cancer prognosis and therapy response: A literature update
Resveratrol binds and activates RKIP protein in colorectal cancer.
TLDR
It is found that resveratrol induced the expression of RKIP at protein levels and the structural arrangements during drug-target interactions were elucidated.
cMET promotes metastasis and epithelial‐mesenchymal transition in colorectal carcinoma by repressing RKIP
TLDR
Overexpression of cMET overexpression may contribute to tumor progression by inhibiting the antioncogene RKIP, providing preclinical justification for targeting RkIP to treat cMET‐induced metastasis of CRC.
Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors.
TLDR
A correlation was identified between high RKIP expression and lesions with a generally improved prognosis, such as those diagnosed in younger patients, in situ lesions and lesions of lower clinical grades; there was also a negative correlation betweenhigh RKip expression and HPV16 positivity in patients.
RKIP reduction enhances radioresistance by activating the Shh signaling pathway in non-small-cell lung cancer
TLDR
RKIP reduction enhances radioresistance by activating the Shh signaling pathway and initiating functional CSCs and this role makes it a promising therapeutic target for improving the efficacy of NSCLC radiation treatment.
Identification of regulatory crosstalks between RKIP and BRCA1 tumor suppressors in healthy tissues and cancer (breast and ovarian): Therapeutic implications
RKIP as an Inflammatory and Immune System Modulator: Implications in Cancer
Raf kinase inhibitor protein (RKIP), an important modulator of intracellular signalling pathways, is commonly downregulated in multiple cancers. This reduction, or loss of expression, is correlated…
RKIP suppresses the proliferation and invasion ofchoriocarcinoma cells through inhibiting the MAPK signaling pathway.
TLDR
The results suggest that RKIP suppresses cell proliferation and invasion in choriocarcinoma cells through inhibiting the MAPK signaling pathway, implying that RkIP may serve as a potential molecular target for the treatment of human choriOCarcinomas.
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References

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TLDR
Results indicate that RKIP is also a metastasis suppressor gene of human epithelial OVCA, and the effect of RKip on the proliferation, migration, or adhesion of OV CA cells is not shown.
Effects of Raf Kinase Inhibitor Protein Expression on Metastasis and Progression of Human Breast Cancer
TLDR
Results indicate that RKIP is a metastasis suppressor gene of human breast cancer, and in the orthotopic murine models, it was observed that overexpression of RkIP in breast cancer cells impaired invasiveness and metastasis, whereas down-regulation of RKip expression promoted invasivity and metastases.
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TLDR
Methylation analysis of 28 cases showed that loss of RKIP expression is unlikely to be due to promoter methylation, which is a marker of tumor progression and distant metastasis in MMR-proficient and MMR-deficient CRCs.
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TLDR
RKIP expression in primary colorectal cancers correlates with overall and disease-free survival, and can be useful for identifying early-stage CRC patients at risk of relapse.
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TLDR
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TLDR
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TLDR
RKIP inhibits the migration and invasion ability of human prostate cancer cells through regulation of the extracellular matrix, and provides new mechanistic insight how RKIP suppresses metastasis in vitro.
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TLDR
These findings reveal two novel signaling pathways targeted by the metastasis suppressor RKIP that regulate remodeling of the extracellular matrix and tumor survival.
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TLDR
EBP1 expression is reduced in adenoid cystic carcinoma, indicating unfavorable prognosis of ACC patients and its regulation of MMP9 and E-cadherin protein levels suggests a critical therapeutic potential.
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