Effect of RGD-disintegrins on melanoma cell growth and metastasis: involvement of the actin cytoskeleton, FAK and c-Fos.

Abstract

The effects and molecular mechanisms of RGD-disintegrins isolated from snake venoms on the growth and metastatic potential of B16F10-melanoma cells were investigated. Jarastatin (JT) from Bothrops jararaca is a ligand of alpha(5)beta(1), alpha(v)beta(3) and alpha(m)beta(2) integrins, flavoridin (FL) from Trimeresurus flavoridis binds preferentially to alpha… (More)

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@article{Oliva2007EffectOR, title={Effect of RGD-disintegrins on melanoma cell growth and metastasis: involvement of the actin cytoskeleton, FAK and c-Fos.}, author={Isabela Batista Oliva and Raphael Molinaro Coelho and Gabriel Gjorup Barcellos and Roberta F Saldanha-Gama and Luciana Serr{\~a}o Wermelinger and Cezary Marcinkiewicz and Russolina Benedeta Zingali and Christina Barja-Fidalgo}, journal={Toxicon : official journal of the International Society on Toxinology}, year={2007}, volume={50 8}, pages={1053-63} }