Effect of Progesterone as a Tocolytic and in Maintenance Therapy during Preterm Labor

@article{Arikan2011EffectOP,
  title={Effect of Progesterone as a Tocolytic and in Maintenance Therapy during Preterm Labor},
  author={Ilker Inan Arikan and Adil Barut and M. Harma and Ibrahim Mehmet Harma},
  journal={Gynecologic and Obstetric Investigation},
  year={2011},
  volume={72},
  pages={269 - 273}
}
Aims: To assess the efficacy of vaginal micronized natural progesterone as a tocolytic and in maintenance therapy during threatened preterm birth. Methods: Eighty-three women with symptoms of threatened preterm birth were either randomized to study groups receiving tocolytic treatment combined with intravaginal micronized natural progesterone (200 mg daily) or to a control group receiving only tocolysis. Results: Micronized natural progesterone treatment resulted in a prolonged latency period… 

Figures and Tables from this paper

The role of micronized progesterone in preterm labour
TLDR
The role of intravaginal micronized progesterone in preterm labour in prolonging the pregnancy up to term and thus improving neonatal outcome was studied to study.
The use of vaginal progesterone as a maintenance therapy in women with arrested preterm labor: a double-blind placebo–randomized controlled trial
  • J. HyettN. Asadi Khadije Bazrafshan
  • Medicine
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
  • 2020
TLDR
Daily administration of 400 mg vaginal progesterone after successful parenteral tocolysis may increase latency preceding delivery and improves cervical shortening and neonatal outcome in women with preterm labor.
Vaginal Progesterone Supplementation in the Management of Preterm Labor: A Randomized Controlled Trial
TLDR
Latency periods were more prolonged in the vaginal progesterone group than in the no-progesterone group, and combined treatment with vaginal progestersone 400 mg could prolong the latency period in preterm labor when compared with no progester one.
Maintenance Treatment With Vaginal Progesterone or Placebo Delayed Preterm Birth More Efficiently Than Intravenous Tocolysis Alone – A Randomized Controlled Trial
TLDR
It is concluded, that the placebo gel reinforced the physiological barrier at the uterine cervix which protects the pregnancy from pathogen invasion and uterine infection leading to preterm birth.
Vaginal Micronized Progesterone and Intramuscular 17α OH Progesterone in Threatened Preterm Labour before 34 Weeks of Gestation
TLDR
Vaginal progesterone was as effective as intramuscular progester one in reducing preterm birth in threatened pretermBirth with fewer side effects in vaginal route, and vaginal group has significantly lesserSide effects in comparison to IM group.
Progesterone as a tocolytic agent for preterm labor: a systematic review
TLDR
Progesterone is currently the most promising agent for maintenance tocolysis, and although further trials are certainly needed, this is an exciting advancement in the realm of to colysis.
COMPARATIVE STUDY TO ASSESS THE EFFICACY BETWEEN INTRAMUSCULAR AND VAGINAL MICRONIZED PROGESTERONE TO PREVENT THREATENED PREMATURE LABOUR
TLDR
Vaginal progesterone was as effective as intramuscular progester one in reducing preterm birth with fewer side effects in favor of vaginal route.
Oral dydrogesterone as an adjunctive therapy in the management of preterm labor: a randomized, double blinded, placebo‐controlled trial
TLDR
Adjunctive treatment with 30 mg of oral dydrogesterone could not prolong latency period in preterm labor when compared to placebo, and there were no differences in the gestational age at delivery, percentage of preterm delivery before 34 weeks and 37 weeks, pregnancy outcomes, neonatal outcomes, compliance and side effects.
Vaginal progesterone for maintenance tocolysis: a systematic review and metaanalysis of randomized trials.
...
...

References

SHOWING 1-10 OF 29 REFERENCES
Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study.
TLDR
Prophylactic vaginal progesterone reduced the frequency of uterine contractions and the rate of preterm delivery in women at high risk for prematurity in a high-risk population.
The use of micronized progesterone in the treatment of menace of preterm delivery.
Oral betamimetics for maintenance therapy after threatened preterm labour.
TLDR
Available evidence does not support the use of oral betamimetics for maintenance therapy after threatened preterm labour, and some adverse effects such as tachycardia were more frequent in the betamametics groups than the groups allocated to placebo, no treatment or another type of tocolytic.
Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate.
BACKGROUND Women who have had a spontaneous preterm delivery are at greatly increased risk for preterm delivery in subsequent pregnancies. The results of several small trials have suggested that 17
Progesterone for preterm birth prevention: an evolving intervention.
  • A. TitaD. Rouse
  • Medicine, Biology
    American journal of obstetrics and gynecology
  • 2009
Progesterone for maintenance tocolytic therapy after threatened preterm labour: A randomised controlled trial
  • S. BornaN. Sahabi
  • Medicine
    The Australian & New Zealand journal of obstetrics & gynaecology
  • 2008
Background:  Women with preterm labour that is arrested with tocolytic therapy are at increased risk of recurrent preterm labour. The efficacy of maintenance tocolytic therapy after successful arrest
...
...