Effect of Pregnancy and Delivery on Cytokine Expression in a Mouse Model of Pelvic Organ Prolapse.

@article{Couri2017EffectOP,
  title={Effect of Pregnancy and Delivery on Cytokine Expression in a Mouse Model of Pelvic Organ Prolapse.},
  author={Bruna M Couri and Andrew T. Lenis and Ali Borazjani and Brian M. Balog and Mei Kuang and Robert S. Butler and Marc S. Penn and Margot S. Damaser},
  journal={Female pelvic medicine & reconstructive surgery},
  year={2017},
  volume={23 6},
  pages={
          449-456
        }
}
OBJECTIVES The aim of this study was to determine the effect of pregnancy and delivery mode on cytokine expression in the pelvic organs and serum of lysyl oxidase like-1 knockout (LOXL1 KO) mice, which develop pelvic organ prolapse after delivery. METHODS Bladder, urethra, vagina, rectum, and blood were harvested from female LOXL1 KO mice during pregnancy, after vaginal or cesarean delivery, and from sham cesarean and unmanipulated controls. Pelvic organs and blood were also harvested from… CONTINUE READING