Effect of Prednisolone on Secondary Messenger Metabolism in the Lymphocytes from Patients with Acantholysis Bullosa

@article{Teplyuk2005EffectOP,
  title={Effect of Prednisolone on Secondary Messenger Metabolism in the Lymphocytes from Patients with Acantholysis Bullosa},
  author={Natalia Teplyuk and Alexander S Dukhanin and Stanislav Ogurtsov and T. S. Belysheva},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2005},
  volume={140},
  pages={323-325}
}
Prednisolone in therapeutic concentrations blocks Ca2+ channels of lymphocyte plasma membranes and prevents arachidonic acid-induced Ca2+ entry into the cells. Glucocorticoid virtually did not modulate arachidonic acid-stimulated release of Ca2+ from intracellular stores. No appreciable effect of the hormone on mitogen-induced changes in the intracellular… CONTINUE READING