Effect of Prediabetes on Membrane Bicarbonate Transporters in Testis and Epididymis

@article{Bernardino2013EffectOP,
  title={Effect of Prediabetes on Membrane Bicarbonate Transporters in Testis and Epididymis},
  author={Raquel Bernardino and Ana Luiza Raffaini Duarte Martins and S{\'i}lvia Socorro and Marco G Alves and Pedro F Oliveira},
  journal={The Journal of Membrane Biology},
  year={2013},
  volume={246},
  pages={877-883}
}
The formation of competent spermatozoa is a complex event that depends on the establishment of adequate environments throughout the male reproductive tract. This includes the control of bicarbonate (HCO3 −) concentration, which plays an essential role in the maintenance of extracellular and intracellular pH (pHi) values. Diabetes mellitus alters pHi regulation in mammalian cells, mainly by altering the activity of ion transporters, particularly HCO3 −-dependent mechanisms. Yet, little is known… CONTINUE READING

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