Effect of Powdered Fermented Milk with Lactobacillus helveticus on Subjects with High-Normal Blood Pressure or Mild Hypertension

@article{Aihara2005EffectOP,
  title={Effect of Powdered Fermented Milk with Lactobacillus helveticus on Subjects with High-Normal Blood Pressure or Mild Hypertension},
  author={Kotaro Aihara and Osami Kajimoto and Hiroshi Hirata and Rei Takahashi and Yasunori Nakamura},
  journal={Journal of the American College of Nutrition},
  year={2005},
  volume={24},
  pages={257 - 265}
}
Objective: Two tripeptides (Val-Pro-Pro and Ile-Pro-Pro) that have inhibitory activities for angiotensin I-converting enzyme are produced in milk fermented with Lactobacillus helveticus. In this study we evaluated the effect and safety of powdered fermented milk with L. helveticus CM4 on subjects with high-normal blood pressure or mild hypertension. Methods: A randomized, placebo-controlled, double-blind study was conducted using 40 subjects with high-normal blood pressure (HN group) and 40… 
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Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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Effects of long-term intake of lactotripeptides on cardiovascular risk factors in hypertensive subjects
TLDR
Ingestion of fermented milk with daily dose of 50 mg of lactotripeptides appears to lower elevated blood pressure slightly from the baseline, but not significantly compared with the placebo group and to induce significant decreases in multiple PL.
The antihypertensive effect of fermented milk in individuals with prehypertension or borderline hypertension.
TLDR
This study does not support earlier studies measuring office BP-measurements, reporting antihypertensive effect of FM, and based on straight performed 24-h ambulatory BP measurements, milk fermented with Lactobacillus helveticus does not posses significant antihyertensive effect.
Enzymatically hydrolyzed lactotripeptides do not lower blood pressure in mildly hypertensive subjects.
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Hypotensive and heart rate-lowering effects in rats receiving milk fermented by specific Lactococcus lactis strains
Previous studies have demonstrated that milk fermented by specific Lactococcus lactis strains significantly inhibits the activity of angiotensin I-converting enzyme (ACE). However, the relationship…
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TLDR
The results do not give notion to the use of fermented milk as treatment for hypertension or as a lifestyle intervention for pre-hypertension nor would it influence population blood pressure.
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IPP-rich milk protein hydrolysate lowers blood pressure in subjects with stage 1 hypertension, a randomized controlled trial
TLDR
MPH1, containing IPP and no minerals, exerts clinically relevant BP lowering effects in subjects with stage 1 hypertension and may be included in lifestyle changes aiming to prevent or reduce high BP.
The effect of yoghurt and its probiotics on blood pressure and serum lipid profile; a randomised controlled trial.
Lactotripeptides Show No Effect on Human Blood Pressure: Results From a Double-Blind Randomized Controlled Trial
TLDR
A randomized double-blind placebo-controlled trial to examine the blood pressure lowering potential of 2 ACE-inhibiting lactotripeptides, ie, Isoleucine- proline-Proline and Valine-proline- Proline does not support the hypothesis of a blood pressure lowered effect.
Lactopeptides and human blood pressure
TLDR
Recent data do not support a role for lactotripeptides in blood pressure regulation, however, there cannot exclude a beneficial effect in hypertensive subjects from specific populations (e.g. Finland, Japan).
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