Effect of Positive Pressure Breathing on Lung Lymph Flow and Water Content in Sheep

@article{Woolverton1978EffectOP,
  title={Effect of Positive Pressure Breathing on Lung Lymph Flow and Water Content in Sheep},
  author={W C Woolverton and Kenneth L. Brigham and Norman C. Staub},
  journal={Circulation Research},
  year={1978},
  volume={42},
  pages={550–557}
}
We studied the effect of 10 cm H2O of continuous positive airway pressure breathing (CPAPB) on steady state lung fluid balance. In 9 of 20 chronically instrumented, unanesthetized sheep, we measured lung lymph flow, pulmonary vascular pressure, cardiac output, pleura pressure, and lymph and plasma protein concentration during a 2-hour baseline period and 3-4 hours of CPAPB. In eight sheep, we measured the same variables after increasing average left atrial pressure by 18 cm H2O to cause mild… 

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