Effect of Polyethylene Glycol 400 on the Intestinal Permeability of Carbamazepine in the Rabbit

@article{Riad1991EffectOP,
  title={Effect of Polyethylene Glycol 400 on the Intestinal Permeability of Carbamazepine in the Rabbit},
  author={Lillian E. Riad and Ronald J. Sawchuk},
  journal={Pharmaceutical Research},
  year={1991},
  volume={8},
  pages={491-497}
}

• Lillian E. Riad, Ronald J. Sawchuk
• Published 1991 in Pharmaceutical Research
• DOI:10.1023/A:1015803312233

Because of the limited solubility of carbamazepine, aqueous solutions are usually prepared using glycols as cosolvents. This research focuses on the effect of varying the composition of polyethylene glycol 400 (PEG-400) in aqueous solutions on rabbit intestinal permeability of carbamazepine in the duodenojejunum and the ascending colon using an in situ perfusion technique. In both segments the intestinal permeability varied inversely with the percentage of PEG-400, when the concentration of… CONTINUE READING

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