Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: a prospective cohort study

@article{Kublin2005EffectOP,
  title={Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: a prospective cohort study},
  author={James G. Kublin and Padmaja Patnaik and Charles S Jere and William C Miller and Irving F. Hoffman and Nelson Chimbiya and Richard Pendame and Terrie E. Taylor and Malcolm Edward Molyneux},
  journal={The Lancet},
  year={2005},
  volume={365},
  pages={233-240}
}
BACKGROUND Raised HIV viral load in blood has been associated with accelerated disease progression and increased transmission of infection. To assess the effect of Plasmodium falciparum malaria on concentrations of HIV in blood, we did a prospective cohort study in Malawi. METHODS We recruited 367 HIV-1-infected adults. Among 334 people aparasitaemic at baseline, 148 had at least one malaria episode during follow-up and received antimalarial treatment. Of these, 77 had HIV-1-RNA measurements… Expand
Prolonged elevation of viral loads in HIV-1-infected children in a region of intense malaria transmission in Northern Uganda
TLDR
Prolonged post-treatment elevation of Plasmodium falciparum malaria is associated with increasing HIV-1 viral loads in children, with some viral loads remaining significantly elevated several weeks after antimalarial treatment. Expand
Presence of Plasmodium falciparum DNA in Plasma Does Not Predict Clinical Malaria in an HIV-1 Infected Population
TLDR
P. falciparum DNA was detected in 8% of participants at baseline, but was not significantly associated with subsequent development of clinical malaria, and HIV PI therapy did not decrease the prevalence of PCR positivity or incidence of clinical disease. Expand
RESEARCH ARTICLE The Association of Falciparum Malaria and HIV/AIDS Infection in Relation to Parasitaemia and Anti- Malarial Treatment Outcome as seen at the Moi Teaching and Referral Hospital in Eldoret, Kenya
TLDR
Investigating the effect of HIV infection on falciparum malaria parasitaemia based on a study conducted at the Moi Teaching and Referral Hospital in Eldoret, Kenya strongly recommends investigative work to be done in view of the recent Kenya Government launch of ACT as a first line treatment for uncomplicated malaria. Expand
Subclinical Plasmodium falciparum Infection and HIV-1 Viral Load
TLDR
It is suggested that low-density malaria infection may not dramatically affect plasma HIV-1 levels in infants, and results of studies of perinatally HIV-infected children in which viral loads were unavailable did not significantly affect development of AIDS-related symptoms. Expand
Effects of HIV-1 infection on malaria parasitemia in milo sub-location, western Kenya
TLDR
The findings showed a higher prevalence of malaria in children aged 2–10 years (73.4%), against the one reported in children in lake Victoria endemic region by the Kenya malaria indicator survey in the year 2010 (38.1%) and HIV-1 status was not found to have effect on malaria infection. Expand
A cross-sectional study of sub-clinical Plasmodium falciparum infection in HIV-1 infected and uninfected populations in Mozambique,
TLDR
Dried blood spots are a convenient and sensitive technique for detecting sub-clinical infection with P. falciparum by nested PCR and should be considered for clinical use among HIV-1 infected persons. Expand
Title A cross-sectional study of subclinical Plasmodium falciparum infection in HIV-1 infected and uninfected populations in Mozambique , South-Eastern Africa Permalink
Background: Plasmodium falciparum and HIV-1 infection cause substantial morbidity and mortality in sub-Saharan Africa. Increasing evidence suggests these two pathogens interact negatively whenExpand
HIV–malaria co-infection: effects of malaria on the prevalence of HIV in East sub-Saharan Africa
TLDR
This is the first study to report malaria as a risk factor of concurrent HIV infection at the population level and emphasizes the need for field studies focused on quantifying the interaction among parasitic infections and risk of HIV infection to explore the impact of control interventions. Expand
Impact of HIV-associated immunosuppression on malaria infection and disease in Malawi.
TLDR
Profoundly Immunosuppressed adults with HIV infection require more-frequent treatment for uncomplicated malaria, but malaria infection and disease are less strongly associated with HIV-associated immunosuppression than are other opportunistic infections. Expand
HIV-malaria co-infection: effects of malaria on the prevalence of HIV in East sub-Saharan Africa.
TLDR
Malaria is reported as a risk factor of concurrent HIV infection at the population level in East sub-Saharan Africa for the first time, and individuals who live in areas with high P. falciparum parasite rate have about twice the risk of being HIV positive. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 28 REFERENCES
The effect of Plasmodium falciparum malaria on HIV-1 RNA blood plasma concentration.
TLDR
HIV-1 blood viral burden is higher in patients with P. falciparum malaria than in controls and this viral burden can, in some patients, be partly reduced with antimalarial therapy. Expand
Effect of HIV-1 and increasing immunosuppression on malaria parasitaemia and clinical episodes in adults in rural Uganda: a cohort study
TLDR
HIV-1 infection is associated with an increased frequency of clinical malaria and parasitaemia, and this association tends to become more pronounced with advancing immunosuppression, and could have important public-health implications for sub-Saharan Africa. Expand
Increasing rates of malarial fever with deteriorating immune status in HIV-1-infected Ugandan adults
TLDR
Data support an interaction between symptomatic P. falciparum and HIV, and suggest an additional HIV-related public health problem in Africa. Expand
Immune activation and induction of HIV-1 replication within CD14 macrophages during acute Plasmodium falciparum malaria coinfection
TLDR
Acute P. falciparum malaria coinfection impacts virus–host dynamics in HIV-1-infected persons at the cellular level, notably showing a reversible induction of HIV- 1 replication in CD14 macrophages that is associated with changes in immune activation. Expand
Impairment of a pregnant woman's acquired ability to limit Plasmodium falciparum by infection with human immunodeficiency virus type-1.
TLDR
The HIV infection diminishes a pregnant woman's capacity to control P. falciparum parasitemia and placental and newborn infection, the major determinants of the impact of P. Falconerum on fetal growth and infant survival. Expand
Comparability of treatment groups and risk factors for parasitemia at the first antenatal clinic visit in a study of malaria treatment and prevention in pregnancy in rural Malawi.
TLDR
Targeting malaria control efforts to women in their first or second pregnancy and during the high transmission season will be an important strategy to reach most parasitemic women and minimize resource expenditure. Expand
What does a single determination of malaria parasite density mean? A longitudinal survey in Mali
TLDR
High parasite density sometimes associated with fever can no longer be considered as the gold standard in the diagnosis of malaria, and other approaches, such as decision‐making processes involving clinical, biological and ecological variables must be developed, especially in highly endemic areas where Plasmodium infection is the rule rather than the exception. Expand
Is there an interaction between human immunodeficiency virus and Plasmodium falciparum?
TLDR
There is no convincing evidence for an interaction between malaria and HIV with the possible exception of an interactions between placental malaria and AIDS, and there is a need for carefully designed studies to resolve whether mortality from severe malaria, in particular cerebral malaria, is increased in HIVSP subjects,Whether malaria infection of the placenta increases the risk of vertical transmission of HIV, and whether malaria infection increases the progression of HIV infection to AIDS. Expand
The natural history of HIV-1 and HIV-2 infections in adults in Africa: a literature review.
TLDR
The majority of patients in hospital in Africa with either HIV-1 or HIV-2 have the clinical features of AIDS just before they die, and many are severely immunosuppressed, similar to the situation in developed countries before the introduction of highly active antiretroviral therapy (HAART). Expand
Sustained plasma TNF-alpha and HIV-1 load despite resolution of other parameters of immune activation during treatment of tuberculosis in Africans.
TLDR
The failure of HIV-1 plasma load to decline significantly during the initial months of anti-tuberculosis treatment is associated with high, sustained systemic levels of TNF-alpha, which may represent dysregulation of cytokine production in these African patients. Expand
...
1
2
3
...