Effect of Placenta Growth Factor-1 on Proliferation and Release of Nitric Oxide, Cyclic AMP and Cyclic GMP in Human Epithelial Cells Expressing the FLT-1 Receptor

@article{Angelucci2001EffectOP,
  title={Effect of Placenta Growth Factor-1 on Proliferation and Release of Nitric Oxide, Cyclic AMP and Cyclic GMP in Human Epithelial Cells Expressing the FLT-1 Receptor},
  author={Cristiana Angelucci and Gina Lama and Fortunata Iacopino and Domenico Maglione and Gigliola Sica},
  journal={Growth Factors},
  year={2001},
  volume={19},
  pages={193 - 206}
}
We investigated the effect of placenta growth factor-1 (PlGF-1) on cell growth and on the release of nitric oxide (NO), cyclic AMP (cAMP) and cyclic GMP (cGMP) in human malignant epithelial cells. A noteworthy increase in proliferation was induced in choriocarcinoma cells (BeWo) by PlGF-1 treatment, while breast cancer cells (CG-5) were minimally affected. Western blotting and immunocytochemistry demonstrated the expression of the PlGF-1 receptor fms-like tyrosine kinase-1 (Flt-1) in these… 
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