Effect of Phenibut and Glufimet, a Novel Glutamic Acid Derivative, on Respiration of Heart and Brain Mitochondria from Animals Exposed to Stress against the Background of Inducible NO-Synthase Blockade

@article{Perfilova2017EffectOP,
  title={Effect of Phenibut and Glufimet, a Novel Glutamic Acid Derivative, on Respiration of Heart and Brain Mitochondria from Animals Exposed to Stress against the Background of Inducible NO-Synthase Blockade},
  author={V. Perfilova and T. A. Popova and I. I. Prokofiev and I. S. Mokrousov and O. V. Ostrovskii and I. Tyurenkov},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2017},
  volume={163},
  pages={226-229}
}
Increased oxygen consumption by heart and brain mitochondria in the absence of ADP and reduced mitochondrial respiration in the presence of ADP were observed in rats exposed to stress simulated by suspension by the dorsal neck skin fold for 24 h, which attests to uncoupling of substrate oxidation and ATP synthesis and can cause electron drain from the respiratory chain, formation of ROS, and oxidative damage to cell structures. Blockade of inducible NO synthase with aminoguanidine (single… Expand
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References

SHOWING 1-10 OF 15 REFERENCES
Aminoguanidine inhibits both constitutive and inducible nitric oxide synthase isoforms in rat intestinal microvasculature in vivo.
TLDR
Although aminoguanidine inhibits these isoforms of NO synthase, it is not a selective inhibitor of the inducible isoform in the intestinal microvasculature in vivo. Expand
Amelioration of immobilization stress-induced biochemical and behavioral alterations and mitochondrial dysfunction by naringin in mice: possible mechanism of nitric oxide modulation.
TLDR
The results suggest the possible involvement of nitrergic pathway in the protective effect of naringin against immobilization stress-induced behavioral, biochemical and mitochondrial dysfunctions in mice. Expand
Chronic Stress Induces the Expression of Inducible Nitric Oxide Synthase in Rat Brain Cortex
TLDR
Investigation of the role of endogenously released nitric oxide in stress and the possible induction of the inducible NO synthase (iNOS) isoform indicates that a sustained overproduction of NO via iNOS expression may be responsible for some of the neurodegenerative changes caused by stress and support a possible neuroprotective role for specific iNos inhibitors in this situation. Expand
Effects of a New Glutamic Acid Derivative on Myocardial Contractility of Stressed Animals under Conditions of Nitric Oxide Synthesis Blockade
TLDR
Adrenoreactivity and increased afterload tests showed that the increment of myocardial contraction/relaxation rates, left-ventricular pressure, and HR were significantly higher in glufimet-treated stressed animals with NO synthesis blockade than in animals which received noglufimet. Expand
[NO-DEPENDENT MECHANISM OF THE CARDIOPROTECTIVE ACTION OF PHENIBUT ON STRESS-INDUCED VIOLATION OF CONTRACTILE FUNCTION OF THE HEART].
TLDR
The results obtained suggest that, for ensuring cardioprotective action of phenibut under conditions of stress-induced myocardial damage, it is necessary to provide for participation of nitric oxide system. Expand
Effect of citrocard on functional activity of cardiomyocyte mitochondria during chronic alcohol intoxication
TLDR
Structural GABA analogue Citrocard (phenibut citrate) and reference preparation piracetam in doses of 50 and 200 mg/kg prevented the damaging effect of alcohol, which was seen from increased indexes of oxidative phosphorylation in treated animals compared to the control group. Expand
Oxidative stress response elicited by mitochondrial dysfunction: Implication in the pathophysiology of aging
TLDR
The positive and integrative roles of mild oxidative stress elicited by mitochondria in the regulation of adaptation, anti-aging and scavenging pathway beyond their roles in the vicious cycle of mitochondrial dysfunction in the aging process are emphasized. Expand
Changes in Oxidant and Antioxidant Status of Females with Experimental Gestosis under the Effect of GABA Derivatives
Experimental gestosis, modeled by replacement of drinking water with 1.8% NaCl solution, induced oxidative stress, which was seen from accumulation of MDA (secondary LPO product) and inhibition ofExpand
Functional assessment of isolated mitochondria in vitro.
TLDR
It is illustrated how careful attention to substrate combinations and inhibitors allows an abundance of unique functional information to be obtained from isolated mitochondria, including function at various energetic states, oxidative capacity with electron flow through distinct complexes, coupling of oxygen consumption to ATP production, and membrane integrity. Expand
Assessing mitochondrial dysfunction in cells
TLDR
Measurement of both respiration and potential during appropriate titrations enables the identification of the primary sites of effectors and the distribution of control, allowing deeper quantitative analyses, as discussed in the present review. Expand
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