Effect of Peroxisome Proliferator-Activated Receptor Gamma Agonist (Pioglitazone) and Methotrexate on Disease Activity in Rheumatoid Arthritis (Experimental and Clinical Study)

@inproceedings{Shahin2011EffectOP,
  title={Effect of Peroxisome Proliferator-Activated Receptor Gamma Agonist (Pioglitazone) and Methotrexate on Disease Activity in Rheumatoid Arthritis (Experimental and Clinical Study)},
  author={Dina A Shahin and Ehab El Toraby and Hala Abdel-Malek and Vivian Boshra and Ayman Zaky Elsamanoudy and Dalia Abdul-Halim Shaheen},
  booktitle={Clinical medicine insights. Arthritis and musculoskeletal disorders},
  year={2011}
}
OBJECTIVE To investigate the combined effect of both pioglitazone and methotrexate on disease activity of rheumatoid arthritis in a biphasic study; experimental and clinical. METHODS EXPERIMENTALLY: 50 rats were divided into 5 equal groups; controls, experimental arthritis, methorexate treated (0.1 mg/Kg daily), pioglitazone-treated (10 mg/kg daily), and methotrexate and pioglitazone treated. Clinically: forty-nine diabetic rheumatoid arthritis patients were included. Patients group consisted… CONTINUE READING
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