Effect of PSK, a protein-bound polysaccharide preparation, on liver tumors of Syrian hamsters induced by Thorotrast injection.

@article{Shiga1993EffectOP,
  title={Effect of PSK, a protein-bound polysaccharide preparation, on liver tumors of Syrian hamsters induced by Thorotrast injection.},
  author={Junji Shiga and Takanori Maruyama and Hidehiko Takahashi and Hiroshi Irie and Taisuke Mori},
  journal={Acta pathologica japonica},
  year={1993},
  volume={43 9},
  pages={475-80}
}
The contrast medium Thorotrast, an agent well known to be carcinogenic, was injected into 400 congeneic Syrian hamsters. The resulting incidence of malignant hepatic tumors such as cholangiocarcinoma, hepatocellular carcinoma and hemangiosarcoma, was significantly higher in the male experimental group than in the control group, and the 50% survival period in the male group was shortened by about 100 days (P < 0.01). However administration of the antitumor drug PSK (Polysaccharide Kureha), a… CONTINUE READING
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