Effect of PPMP on apoptosis-related genes in human leukemia multidrug resistance cell strain K562/AO2 GCS

@inproceedings{Li2012EffectOP,
  title={Effect of PPMP on apoptosis-related genes in human leukemia multidrug resistance cell strain K562/AO2 GCS},
  author={Yulin Li},
  year={2012}
}
Objective To explore the effect of 1-phenyl-2-palmitoylamino-3-morpholino-1-propanal(PPMP) on glucosylceramide synthase gene(GCS)-induced multidrug resistance human leukemia cell strain K562/AO2 and apoptosis-related genes.Methods The K562/AO2 cells were treated with PPMP,the mRNA expressions of GCS,Bcl-2 and Bax were analyzed with RT-PCR.Results PPMP could inhibit GCS mRNA expression in K562/AO2 cell strain with downregulating Bcl-2 mRNA expression,but without apparent change of Bax mRNA… CONTINUE READING

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