Effect of PKG activation on recombinant GABAA receptors.

@article{Leidenheimer1996EffectOP,
  title={Effect of PKG activation on recombinant GABAA receptors.},
  author={Nancy J. Leidenheimer},
  journal={Brain research. Molecular brain research},
  year={1996},
  volume={42 1},
  pages={131-4}
}
The effect of cGMP-dependent protein kinase (PKG) on recombinant human alpha 1 beta 2 gamma 2L GABAA receptors expressed in Xenopus oocytes was studied using the two-electrode voltage-clamp technique. The cGMP analog 8BrcGMP (1 mM) produced an increase in GABA-gated chloride currents. Intracellular injection of the PKG inhibitor peptide, PKGI, prevented the 8BrcGMP-mediated increase in the GABA response indicating that 8BrcGMP enhances GABAA receptor function via activation of PKG. Previous… CONTINUE READING

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