Effect of PKG activation on recombinant GABAA receptors.

  title={Effect of PKG activation on recombinant GABAA receptors.},
  author={Nancy J. Leidenheimer},
  journal={Brain research. Molecular brain research},
  volume={42 1},
The effect of cGMP-dependent protein kinase (PKG) on recombinant human alpha 1 beta 2 gamma 2L GABAA receptors expressed in Xenopus oocytes was studied using the two-electrode voltage-clamp technique. The cGMP analog 8BrcGMP (1 mM) produced an increase in GABA-gated chloride currents. Intracellular injection of the PKG inhibitor peptide, PKGI, prevented the 8BrcGMP-mediated increase in the GABA response indicating that 8BrcGMP enhances GABAA receptor function via activation of PKG. Previous… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 12 extracted citations

The induction of pain: an integrative review

Progress in Neurobiology • 1999
View 5 Excerpts
Highly Influenced

Guanylyl cyclase stimulatory coupling to K(Ca) channels.

American journal of physiology. Cell physiology • 2000
View 1 Excerpt

Similar Papers

Loading similar papers…