Effect of PJ-34 PARP-inhibitor on rat liver microcirculation and antioxidant status.

@article{Szjrt2007EffectOP,
  title={Effect of PJ-34 PARP-inhibitor on rat liver microcirculation and antioxidant status.},
  author={Attila Sz{\'i}j{\'a}rt{\'o} and Enkhjargal Batmunkh and Oszk{\'a}r Hahn and Zolt{\'a}n Mih{\'a}ly and Ad{\'a}m Kreiss and Andr{\'a}s Kiss and G{\'a}bor Lotz and Zsuzsa Schaff and L{\'a}szl{\'o} V{\'a}li and Anna Bl{\'a}zovics and Domokos Gerő and Csaba Szab{\'o} and P{\'e}ter K{\'a}roly Kupcsulik},
  journal={The Journal of surgical research},
  year={2007},
  volume={142 1},
  pages={72-80}
}
BACKGROUND Ischemia-reperfusion (I-R) injury during liver resection leads to the production of toxic free radicals and oxidants that influence the microcirculation. DNA single-strand breaks can be induced by these reactive species. In response to excessive DNA damage, PARP [poly(ADP-ribose) polymerase] becomes overactivated, which can lead to cellular ATP depletion and cell death. The aim of our study was to evaluate whether PARP is expressed in post-ischemic liver, and to examine the effect of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…