Effect of PGE2 and alpha-adrenergic agonists on AVP-dependent cAMP levels in rabbit and rat CCT.

@article{Chabards1988EffectOP,
  title={Effect of PGE2 and alpha-adrenergic agonists on AVP-dependent cAMP levels in rabbit and rat CCT.},
  author={Danielle Chabard{\`e}s and Chehrazade Brick-Ghannam and Madeleine Mont{\'e}gut and Sylvie Siaume-Perez},
  journal={The American journal of physiology},
  year={1988},
  volume={255 1 Pt 2},
  pages={F43-8}
}
The effect of prostaglandins and alpha-adrenergic agonists on arginine vasopressin-induced adenosine 3',5'-cyclic monophosphate (cAMP) production was investigated in microdissected rat and rabbit cortical collecting tubules (CCT) incubated in vitro. In rabbit CCT, addition to all media of a prostaglandin synthesis inhibitor increased this production; exogenous prostaglandin E2 (PGE2) induced a reproducible dose-dependent inhibition of cAMP accumulation. Maximal inhibition (mean: 57.5%) was… CONTINUE READING
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