Effect of PEO surface density on long-circulating PLA-PEO nanoparticles which are very low complement activators.

@article{Vittaz1996EffectOP,
  title={Effect of PEO surface density on long-circulating PLA-PEO nanoparticles which are very low complement activators.},
  author={M Vittaz and Didier Bazile and G Spenlehauer and T Verrecchia and M. Veillard and Francis Puisieux and Denis Labarre},
  journal={Biomaterials},
  year={1996},
  volume={17 16},
  pages={1575-81}
}
The rapid uptake of injected nanoparticles by cells of the mononuclear phagocytes system (MPS) is a major obstacle when a long blood circulation time is needed. Whereas nanoparticles made from PLA and stabilized by surfactants (PLA-F68) are rapidly phagocytized, the rate of phagocytosis is strongly reduced in case of nanoparticles made from a diblock copolymer (PLA-PEO). Because of the role of the complement system in opsonization, this difference of phagocytosis was hypothesized to be related… CONTINUE READING