Effect of PEGylated Magnetic PLGA-PEI Nanoparticles on Primary Hippocampal Neurons: Reduced Nano-neurotoxicity and Enhanced Transfection Efficiency with Magnetofection.

@article{Cui2019EffectOP,
  title={Effect of PEGylated Magnetic PLGA-PEI Nanoparticles on Primary Hippocampal Neurons: Reduced Nano-neurotoxicity and Enhanced Transfection Efficiency with Magnetofection.},
  author={Yanna Cui and Xiao Li and Kristina Zeljic and Shifang Shan and Zilong Qiu and Zhaofang Wang},
  journal={ACS applied materials \& interfaces},
  year={2019}
}
Despite broad application of nanotechnology in neuroscience, the nano-neurotoxicity of magnetic nanoparticles in primary hippocampal neurons remains poorly characterized. In particular, understanding how magnetic nanoparticles perturb neuronal calcium homeostasis is critical when considering magnetic nanoparticles as a non-viral vector for effective gene therapy in neuronal diseases. Here, we address the pressing need to systematically investigate the neurotoxicity of magnetic nanoparticles… 

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