Effect of PCBs on androgen production by suspension of adult rat Leydig cells in vitro

@article{Kovaevi1995EffectOP,
  title={Effect of PCBs on androgen production by suspension of adult rat Leydig cells in vitro},
  author={Radmila M. Kova{\vc}evi{\'c} and Mirjana B Vojinovic-Miloradov and Ivana Teodorovic and Silvana Andri{\'c}},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={1995},
  volume={52},
  pages={595-597}
}
The effects of PCBs (mixture of 2, 3, 4, 5-tetra; 2, 2', 4, 5, 5'-penta; 2, 2', 3, 3', 6, 6'-hexa and 2, 2', 3, 3', 4, 4', 5, 5'-octa congeners) on androgen production were investigated by suspension of Leydig cells from adult rat testis. hCG-stimulated androgen production was significantly inhibited by PCBs while progesterone level was not affected. Progesterone supported testosterone production was also decreased by PCBs, while conversion of androstenedione to testosterone was unchanged… CONTINUE READING
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