Effect of P2X4R on airway inflammation and airway remodeling in allergic airway challenge in mice.

@article{Chen2016EffectOP,
  title={Effect of P2X4R on airway inflammation and airway remodeling in allergic airway challenge in mice.},
  author={Hong-xia Chen and Qingqing Xia and Xiaoqian Feng and Fangyuan Cao and Hang Yu and Yinli Song and Xiuqin Ni},
  journal={Molecular medicine reports},
  year={2016},
  volume={13 1},
  pages={
          697-704
        }
}
P2X4 receptor (P2X4R) is the most widely expressed subtype of the P2XRs in the purinergic receptor family. Adenosine triphosphate (ATP), a ligand for this receptor, has been implicated in the pathogenesis of asthma. ATP‑P2X4R signaling is involved in pulmonary vascular remodeling, and in the proliferation and differentiation of airway and alveolar epithelial cell lines. However, the role of P2X4R in asthma remains to be elucidated. This aim of the present study was to investigate the effects of… CONTINUE READING
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