Effect of Orotic Acid on Vitamin B12-deficient Rats

@article{Marchetti1956EffectOO,
  title={Effect of Orotic Acid on Vitamin B12-deficient Rats},
  author={M. Marchetti and R. Viviani and A. Rabbi},
  journal={Nature},
  year={1956},
  volume={178},
  pages={805-805}
}
STUDIES in this laboratory1,2 have recently shown that orotic acid is a factor for growth and survival in rats depleted of the animal protein factor of casein. Also, vitamin B12 has a protective effect on the deficiency in animal protein factor3. This indicates a relationship, from a nutritional point of view, between vitamin B12 and orotic acid. In the present communication the direct influence of orotic acid upon the deficiency of vitamin B12 is reported. 
10 Citations

Topics from this paper

A NEW GROWTH factor.
Effect of orotic acid on development of erythrocytes and granulocytes in the bone marrow