Effect of Orotic Acid on Vitamin B12-deficient Rats

  title={Effect of Orotic Acid on Vitamin B12-deficient Rats},
  author={M. Marchetti and R. Viviani and A. Rabbi},
STUDIES in this laboratory1,2 have recently shown that orotic acid is a factor for growth and survival in rats depleted of the animal protein factor of casein. Also, vitamin B12 has a protective effect on the deficiency in animal protein factor3. This indicates a relationship, from a nutritional point of view, between vitamin B12 and orotic acid. In the present communication the direct influence of orotic acid upon the deficiency of vitamin B12 is reported. 
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