Effect of Oophorectomy on Survival After Breast Cancer in BRCA1 and BRCA2 Mutation Carriers.

@article{Metcalfe2015EffectOO,
  title={Effect of Oophorectomy on Survival After Breast Cancer in BRCA1 and BRCA2 Mutation Carriers.},
  author={Kelly A Metcalfe and Henry T. Lynch and William D Foulkes and Nadine M. Tung and C Kim-sing and Olufunmilayo I. Olopade and Andrea Eisen and Barry P. Rosen and Carrie L. Snyder and Shelley Gershman and Ping Sun and Steven A Narod},
  journal={JAMA oncology},
  year={2015},
  volume={1 3},
  pages={
          306-13
        }
}
IMPORTANCE Women who carry a germline mutation in either the BRCA1 or BRCA2 gene face a lifetime risk of breast cancer of up to 70%, and once they receive a diagnosis of breast cancer, they face high risks of both second primary breast and ovarian cancers. Preventive bilateral salpingo-oophorectomy is recommended to women with a BRCA mutation at age 35 years or thereafter to prevent breast and ovarian cancer, but it is unclear whether oophorectomy has an impact on survival in women with BRCA… CONTINUE READING
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