Effect of Oleic Acid on the Permeation Kinetics of Diclofenac Diethylamine

  title={Effect of Oleic Acid on the Permeation Kinetics of Diclofenac Diethylamine},
  author={Syed Nisar Hussain Shah and Muhammad Salman and M. Ahmad and Mahboob Rabbani and Amir Badshah},
In vitro permeation studies were done using modified Franz diffusion cell through rabbit skin and silicone membrane utilizing different ratios of oleic acid with diclofenac diethylamine (DDA) in normal saline and methanol mixture during present study. Solubility studies indicated linear increase in drug solubility with carrier concentration. The enhancing effect of all the enhancer’s ratios was found to be significantly greater than that of standard without enhancer (control). ‘Benchmark… CONTINUE READING


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